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    1. Computational and Systems Biology
    2. Evolutionary Biology

    Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

    Kara Schmidlin, Sam Apodaca ... Kerry Geiler-Samerotte
    Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to environmental change.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    ImmCellTyper facilitates systematic mass cytometry data analysis for deep immune profiling

    Jing Sun, Desmond Choy ... Shahram Kordasti
    ImmCellTyper enhances CyTOF data analysis by combining expert biological knowledge with advanced clustering tools to provide an accurate, comprehensive, and user-friendly solution for high-dimensional immune profiling.
    1. Computational and Systems Biology
    2. Ecology

    A rapid phylogeny-based method for accurate community profiling of large-scale metabarcoding datasets

    Lenore Pipes, Rasmus Nielsen
    Tronko provides a scalable solution for accurate taxonomic assignment for large-scale metabarcoding datasets by overcoming the speed and memory limitations of previous phylogenetic placement methods.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    MDverse, shedding light on the dark matter of molecular dynamics simulations

    Johanna KS Tiemann, Magdalena Szczuka ... Pierre Poulain
    Identifying, indexing, and annotating molecular dynamics simulations open data is essential to ensure their proper reuse.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

    Wei-Ping Li, Jia-Ying Su ... Chien-Ling Lin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    Alleviating cell-free DNA sequencing biases with optimal transport

    Antoine Passemiers, Tatjana Jatsenko ... Yves Moreau
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    ASBAR: an Animal Skeleton-Based Action Recognition framework. Recognizing great ape behaviors in the wild using pose estimation with domain adaptation

    Michael Fuchs, Emilie Genty ... Paul Cotofrei
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum: A containment strategy for toxic intermediates

    Samantha J Ziegler, Brandon C Knott ... Yannick J Bomble
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Cancer Biology

    Computational Engineering of a Therapeutic Antibody to Inhibit Multiple Mutants of HER2 Without Compromising Inhibition of the Canonical HER2

    Sapir Peled, Julia Guez-Haddad ... Yanay Ofran
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology

    Convergent evolution in silico reveals shape and dynamic principles of directed locomotion

    Renata B Biazzi, André Fujita, Daniel Y Takahashi
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
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