Browse our latest Computational and Systems Biology articles

Comparing tissue-specific plasma cfDNA concentration with cellular turnover rates reveals that less than 10% of dying cells' DNA reaches plasma, highlighting significant local clearance mechanisms and suggesitng approaches to enhance liquid biopsy sensitivity.

Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO₂.

High-resolution simulations of evolving microbial populations reveal that microscopic epistasis slows the rate of adaptation, while clonal interference can either speed it up or leave it fixed.

The transition from a restrictive patterning mechanism to one sensitive to a variety of environmental cues in NOTCH-mediated angiogenesis offers crucial insights into vascularization in damaged organs and cancer therapy.

A mammalian protein with RNA recognition motifs can be used in bacteria to engineer post-transcriptional regulation.

Combining biophysically realistic hippocampal neurons with coupled phase oscillators that represent theta inputs enables probing the phase-dependent effects of neurostimulation on theta-nested gamma oscillations in normal and pathological states.

A new study reveals structural details of the bacterial essential interactome, opening new avenues for antibiotic discovery.

A computer model predicts different mechanisms of blood pressure regulation and effective hypertensive therapy for males and females, thereby serving as a foundational tool for improved treatment precision.

Genetic background and dietary environment interact to reshape metabolic signalling networks, and the resulting signalling diversity can illuminate regulatory mechanisms of complex traits.