Browse our latest Computational and Systems Biology articles

A high-throughput enhancer-enhancer-promoter reporter assay indicates that pairs of enhancers generally activate promoters in a near-additive manner, and that promoters transform their collective effect non-linearly.

The DGRPool web tool aggregates phenotyping data from the Drosophila Genetic Reference Panel, streamlining genetic association studies and offering new insights into genetic and phenotypic variation in complex traits.

Understanding metabolic interactions and successive cross-feeding in native microbiomes illuminates the mechanisms behind plant disease promotion and suppression, enhancing our ability to manipulate microbiomes toward specific functions of interest.

Comparison between tapping performance of humans during a synchronization task and new metrics that characterize the U-fiber system of white matter revealed large intersubject correlations between phase accuracy at specific tempos and the strength of connectivity in their audiomotor system.

Estimating the organization of supraspinal input to motoneurons in humans is not currently possible, but a promising reverse engineering technique has been developed using large-scale supercomputing and computational neuroscience.

Introducing the optorepressilator, a synthetic genetic oscillator that can be synchronized, entrained, and detuned by green light to precisely control periodic gene expression in single cells or entire bacterial populations.

A multi-disciplined approach uncovered microRNA-199a/b-5p as important regulators of chondrogenesis, which negatively regulate mRNAs such as FZD6, ITGA3, and CAV1 for protective purposes during chondrogenesis.

Nanopore sequencing effectively resolves key challenges in bacterial small variant detection, providing a more accurate alternative to traditional sequencing methods.