Browse our latest Computational and Systems Biology articles

Collaborative hunting, characterized by the division of roles among predators, has emerged within a group of artificial agents through deep reinforcement learning.

A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.

MetaPathPredict is a novel bioinformatics tool that makes accurate predictions of KEGG module presence within highly incomplete bacterial genomes.

Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.

ElegansBot, a two-dimensional rigid body chain model, simulates various locomotion of C. elegans, including omega and delta turns, using Newtonian equations of motion.

Genetic variants interact with open chromatin to alter gene expression within topologically associated domains of DNA in outbred mice.

A top-down model-guided framework unveils the role of regulatory logics underlying gene regulatory networks in cell fate decisions.

Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.

Integration of language model and geometric deep learning enables accurate and efficient genome-scale annotation of comprehensive protein-ligand binding sites.