Browse our latest Computational and Systems Biology articles

A computational approach examines the roles of splicing factors and their association with evolutionary change in splicing.

Bactabolize is a pipeline for rapid and scalable production of accurate bacterial strain-specific metabolic models and growth phenotype predictions.

A meta-analysis of single-cell data reveals an advanced and conserved polarisation state of SPP1⁺ macrophages in multiple human fibrotic tissues.

Single-cell data on cell signaling responses to nutrient variation enable quantitative models of cellular control over protein synthesis, formalizing the concept of mTOR as a homeostatic controller of cellular metabolism.

Large-scale screens and computational approaches reveal phenotypes for 3492 genes and gene-ontology predictions for 783 genes, including hitherto unstudied genes, which provides a potent platform to further dissect protein function.

Classical theoretical approaches to studying the cerebellar cortex are generalized to a broader set of learning tasks, revealing that the optimal value for the sparsity of granule cell activity is task-dependent.