High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
Mathematical modeling shows how RAF inhibitors can actually activate RAF kinases by stabilizing RAF proteins in the conformation capable of dimerization.
Isoform-specific variations in doublecortin-like kinases offer a new framework for understanding kinome-wide modulation of protein stability and catalytic activity.
Morphological profiling of untreated HCT116 cells using Cell Painting reveals a signature of bortezomib resistance, providing a proof-of-concept for the unbiased analysis of drug resistance.
Mohamad Ibrahim Cheikh, Joel Tchoufag ... Konstantin Doubrovinski
Direct mechanical microcantilever-based measurements establish key material parameters describing mechanical response of the early Drosophila embryonic epithelium.
Yingnan Zhang, Kelly Zhang ... Natalia A Trayanova
A novel computational approach integrates personal genetics into personalized whole heart digital twins to predict ventricular arrhythmia circuits for patients with arrhythmogenic right ventricular cardiomyopathy.