Browse our latest Computational and Systems Biology articles

Page 19 of 115
    1. Computational and Systems Biology

    Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells

    Silvia Liu, Yan-Ping Yu ... Jian-Hua Luo
    A synthetic long-read single-cell sequencing reveals critical mutation isoform expression patterns in human liver cancer cells.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting

    Ian R Outhwaite, Sukrit Singh ... Markus A Seeliger
    Combinations of inhibitors can more selectively inhibit individual or multiple protein kinases than single inhibitors.
    1. Computational and Systems Biology
    2. Neuroscience

    Interpersonal alignment of neural evidence accumulation to social exchange of confidence

    Jamal Esmaily, Sajjad Zabbah ... Bahador Bahrami
    A multidisciplinary approach sheds light on the fundamental mechanisms underlying social belief communication under uncertainty.
    1. Computational and Systems Biology

    Predicting the effect of CRISPR-Cas9-based epigenome editing

    Sanjit Singh Batra, Alan Cabrera ... Yun S. Song
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology

    Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease

    Ricardo Omar Ramirez Flores, Jan David Lanzer ... Julio Saez-Rodriguez
    A computational framework allows the unsupervised analysis of samples from single cell data across conditions, inference of multicellular programs associated with disease, and meta-analysis of independent patient cohorts.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Special Issue: Systems Genetics

    Edited by David James et al.
    In this Special Issue we present a range of studies that showcase novel approaches that researchers are exploring to better decipher the link between genotype and phenotype.
    1. Computational and Systems Biology
    2. Neuroscience

    A computationally informed comparison between the strategies of rodents and humans in visual object recognition

    Anna Elisabeth Schnell, Maarten Leemans ... Hans Op de Beeck
    Using a computational approach for designing object recognition tasks is beneficial to highlight the different strategies among different species.