Browse our latest Computational and Systems Biology articles

A novel bilinear modeling approach reveals genetic code of neuronal connectivity, offering insights for targeted genetic interventions in neural circuits.

Advanced statistical and computational methods are reviewed and compared for integrating microbiome, host genomics, and metabolomics data, together with future research directions.

Phantasus democratizes gene expression analysis, offering intuitive and interactive tools that streamline the exploration and analysis of user-provided data and over 96,000 public datasets.

A computational model of skeletal muscle regeneration reveals complex interplay of cytokines, angiogenesis, and cell behaviors, predicting that synergistic cytokine perturbations enhance skeletal muscle regeneration beyond individual cytokine interventions.

Three theoretical principles explain the neural activity observed in the head direction circuit of insects, the connectivity pattern underlying the circuit, and how the ubiquitous eight-column circuit structure emerged from evolutionary processes.

Those quoted and mentioned in stories in Nature News mostly have names associated with men and are much less likely to have names associated with East Asia.

Estimating cell type composition from a gene expression mixture remains a challenging task, as evidenced by how a simple regression model outperforms many state-of-the-art spatial deconvolution methods.

Bacterial Type IV restriction-modification systems display remarkable, previously unnoticed diversity of complex gene and domain architectures, and are predicted to couple antiphage immunity with the abortive infection form of defense.