Browse our latest Computational and Systems Biology articles

Page 21 of 125
    1. Computational and Systems Biology

    TopOMetry systematically learns and evaluates the latent dimensions of single-cell atlases

    Davi Sidarta-Oliveira, Ana Domingos, Licio A Velloso
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Combining mutation and recombination statistics to infer clonal families in antibody repertoires

    Natanael Spisak, Gabriel Athènes ... Aleksandra M Walczak
    HILARy is a new algorithm for grouping B-cell receptor sequences into distinct lineages, a crucial task to analyze immune response and memory through repertoire sequencing.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action

    Ritwik Maity, Xuepei Zhang ... Javier Sancho
    Like two peas in a pod but not exactly alike, similar molecules targeting the same bacterial protein behave differently, requiring systems biology and target deconvolution to gain better comprehension.
    1. Computational and Systems Biology

    Establishing comprehensive quaternary structural proteomes from genome sequence

    Edward Alexander Catoiu, Nathan Mih ... Bernhard Palsson
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Computational and Systems Biology

    Identifying images in the biology literature that are problematic for people with a color-vision deficiency

    Harlan P Stevens, Carly V Winegar ... Stephen R Piccolo
    Approximately 13% of figures in biology-related research articles are difficult for people with red/green colorblindness to decipher, but machine-learning models can help to identify these.
    1. Neuroscience
    2. Computational and Systems Biology

    Visual information is broadcast among cortical areas in discrete channels

    Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology

    A three filament mechanistic model of musculotendon force and impedance

    Matthew Millard, David W Franklin, Walter Herzog
    Benchmark simulations show that the VEXAT muscle model is more accurate than a Hill-type muscle model at mimicking the response of biological muscle to length changes great and small.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs

    Kara Schmidlin, Sam Apodaca ... Kerry Geiler-Samerotte
    Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to environmental change.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    ImmCellTyper facilitates systematic mass cytometry data analysis for deep immune profiling

    Jing Sun, Desmond Choy ... Shahram Kordasti
    ImmCellTyper enhances CyTOF data analysis by combining expert biological knowledge with advanced clustering tools to provide an accurate, comprehensive, and user-friendly solution for high-dimensional immune profiling.
    1. Computational and Systems Biology
    2. Ecology

    A rapid phylogeny-based method for accurate community profiling of large-scale metabarcoding datasets

    Lenore Pipes, Rasmus Nielsen
    Tronko provides a scalable solution for accurate taxonomic assignment for large-scale metabarcoding datasets by overcoming the speed and memory limitations of previous phylogenetic placement methods.