Browse our latest Computational and Systems Biology articles

Page 26 of 114
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function

    Tal Ben Yaakov, Tanya Wasserman ... Yonatan Savir
    The ovarian immune system ages while coping with the two main challenges of the aging ovary before menopause, the inflammatory stimulations due to repeated cycles and the increasing need for clearance of accumulating atretic follicles.
    1. Computational and Systems Biology
    2. Medicine

    Local generation and efficient evaluation of numerous drug combinations in a single sample

    Vlad Elgart, Joseph Loscalzo
    Engineered local heterogeneity in drug concentration is used as a tool to encode drug treatment regimens and to predict the macroscopic cellular response to drug perturbations.
    1. Computational and Systems Biology
    2. Neuroscience

    Principles for coding associative memories in a compact neural network

    Christian Pritz, Eyal Itskovits ... Alon Zaslaver
    A compact neural network can form various associative memories that are encoded in a distributed manner, where each neuron stores different components of the memory.
    1. Computational and Systems Biology
    2. Neuroscience

    Memory: When neurons split the load

    Itamar Lev, Manuel Zimmer
    Various aspects of olfactory memory are represented as modulated responses across different classes of neurons in C. elegans.
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    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Improved T cell receptor antigen pairing through data-driven filtering of sequencing information from single cells

    Helle Rus Povlsen, Amalie Kai Bentzen ... Morten Nielsen
    A bioinformatics approach shows how to reduce noise in single-cell TCR-pMHC specificity data while retaining sensitivity toward cross-binding events to facilitate investigation of the rules governing TCR-pMHC binding.
    1. Computational and Systems Biology
    2. Neuroscience

    Metabolic activity organizes olfactory representations

    Wesley W Qian, Jennifer N Wei ... Alexander B Wiltschko
    Metabolic activity across all living things represents an organizing principle for the sense of smell in humans and animals.
    1. Computational and Systems Biology
    2. Developmental Biology

    Patterning precision under non-linear morphogen decay and molecular noise

    Jan Andreas Adelmann, Roman Vetter, Dagmar Iber
    Statistical analysis of morphogen gradients indicates that non-linear morphogen decay does not lead to significantly increased patterning precision, and in fact, the opposite is observed far from the source.
    1. Cancer Biology
    2. Computational and Systems Biology

    Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

    Simon Grund Sørensen, Amruta Shrikhande ... Jakob Skou Pedersen
    Deficiencies of several DNA damage response genes can be predicted by their association with genome-wide mutation patterns.
    1. Computational and Systems Biology

    Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock

    Sara Ahadi, Kenneth A Wilson ... Ali Bashir
    Deep learning on fundus images provides a non-invasive, short time-scale biological aging clock that successfully identifies aging genes validated in a fly model.
    1. Computational and Systems Biology
    2. Ecology

    Emergent regulation of ant foraging frequency through a computationally inexpensive forager movement rule

    Lior Baltiansky, Guy Frankel, Ofer Feinerman
    Rather than complex decisions, it is the motion of individuals that allows for collective foraging regulation in ant colonies.