Browse our latest Computational and Systems Biology articles

Page 26 of 127
    1. Computational and Systems Biology

    Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regions

    Apiwat Sangphukieo, Pitiporn Noisagul ... Parunya Chaiyawat
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    Analysis of science journalism reveals gender and regional disparities in coverage

    Natalie R Davidson, Casey S Greene
    Those quoted and mentioned in stories in Nature News mostly have names associated with men and are much less likely to have names associated with East Asia.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Spotless, a reproducible pipeline for benchmarking cell type deconvolution in spatial transcriptomics

    Chananchida Sang-aram, Robin Browaeys ... Yvan Saeys
    Estimating cell type composition from a gene expression mixture remains a challenging task, as evidenced by how a simple regression model outperforms many state-of-the-art spatial deconvolution methods.
    1. Computational and Systems Biology
    2. Cancer Biology

    Comparison of Tug-of-War Models Assuming Moran versus Branching Process Population Dynamics

    Khanh N. Dinh, Monika K. Kurpas, Marek Kimmel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Inadequate
    1. Computational and Systems Biology
    2. Evolutionary Biology

    CoCoNuTs are a diverse subclass of Type IV restriction systems predicted to target RNA

    Ryan T Bell, Harutyun Sahakyan ... Eugene V Koonin
    Bacterial Type IV restriction-modification systems display remarkable, previously unnoticed diversity of complex gene and domain architectures, and are predicted to couple antiphage immunity with the abortive infection form of defense.
    1. Computational and Systems Biology

    Improved clinical data imputation via classical and quantum determinantal point processes

    Skander Kazdaghli, Iordanis Kerenidis ... Philip Teare
    A new data imputation method that can be implemented quantumly allows for better and more reliable classifications.
    1. Neuroscience
    2. Computational and Systems Biology

    Testing the state-dependent model of subsecond time perception against experimental evidence

    Pirathitha Ravichandran-Schmidt, Joachim Hass
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    Heritable epigenetic changes are constrained by the dynamics of regulatory architectures

    Antony M Jose
    A foundation for analyzing epigenetic changes within the context of regulatory architectures that enable heredity.
    1. Computational and Systems Biology
    2. Ecology

    Collaborative hunting in artificial agents with deep reinforcement learning

    Kazushi Tsutsui, Ryoya Tanaka ... Keisuke Fujii
    Collaborative hunting, characterized by the division of roles among predators, has emerged within a group of artificial agents through deep reinforcement learning.
    1. Computational and Systems Biology
    2. Developmental Biology

    The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

    Arya Y Nakhe, Prasanna K Dadi ... David A Jacobson
    A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.