Browse our latest Computational and Systems Biology articles

Computational models and mutagenesis study reveal a conserved carbohydrate recognition motif of two therapeutically important purinergic receptors to help understand the carbohydrate regulation of G-protein coupled receptors.

Coccinella, an open-source framework, combines real-time tracking on microcomputers with statistical learning, optimising behaviour analysis in Drosophila melanogaster while surpassing other advanced systems in throughput and performance.

High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.

Mathematical modeling shows how RAF inhibitors can actually activate RAF kinases by stabilizing RAF proteins in the conformation capable of dimerization.

The cellular membrane competes with Abl for myristoyl binding to stabilize the preactivated state and enhance allosteric activation.

Isoform-specific variations in doublecortin-like kinases offer a new framework for understanding kinome-wide modulation of protein stability and catalytic activity.

Gene expression profiling of a diverse mouse population helps to decipher how a fat-rich diet contributes to inflammatory bowel disease.

A strategy combining large mouse and human genetic data sheds light on dietary and genetic drivers of gut inflammation.

Morphological profiling of untreated HCT116 cells using Cell Painting reveals a signature of bortezomib resistance, providing a proof-of-concept for the unbiased analysis of drug resistance.