Browse our latest Computational and Systems Biology articles

Page 28 of 123
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

    David J Torres, Paulus Mrass ... Judy L Cannon
    The analysis of T cell movement in multiple tissues (lymph node, villi, and lung under two different inflammatory conditions) sheds new light on how T cells navigate different tissue environments to improve immunity and search processes.
    1. Cancer Biology
    2. Computational and Systems Biology

    Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records

    Jessica Xin Hjaltelin, Sif Ingibergsdóttir Novitski ... Søren Brunak
    A comprehensive comparison of the two types of pancreatic cancer symptom trajectories can in combination leverage a fuller potential of large health data and ultimately aid the detection of early risk factors for pancreatic cancer.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems genetics approaches for understanding complex traits with relevance for human disease

    Hooman Allayee, Charles R Farber ... Aldons J Lusis
    Systems genetics is a powerful approach that links DNA variation to complex clinical and physiological traits through the integration of intermediate phenotypes, such as RNA, protein, and metabolite levels.
    1. Computational and Systems Biology

    Identification of a carbohydrate recognition motif of purinergic receptors

    Lifen Zhao, Fangyu Wei ... Xi Cheng
    Computational models and mutagenesis study reveal a conserved carbohydrate recognition motif of two therapeutically important purinergic receptors to help understand the carbohydrate regulation of G-protein coupled receptors.
    1. Computational and Systems Biology
    2. Neuroscience

    A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster

    Hannah Jones, Jenny A Willis ... Giorgio F Gilestro
    Coccinella, an open-source framework, combines real-time tracking on microcomputers with statistical learning, optimising behaviour analysis in Drosophila melanogaster while surpassing other advanced systems in throughput and performance.
    1. Computational and Systems Biology
    2. Ecology

    100 years of anthropogenic impact causes changes in freshwater functional biodiversity

    Niamh Eastwood, Jiarui Zhou ... Luisa Orsini
    High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Theoretical analysis reveals a role for RAF conformational autoinhibition in paradoxical activation

    Gaurav Mendiratta, Edward Stites
    Mathematical modeling shows how RAF inhibitors can actually activate RAF kinases by stabilizing RAF proteins in the conformation capable of dimerization.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Myristoyl’s dual role in allosterically regulating and localizing Abl kinase

    Svenja de Buhr, Frauke Gräter
    The cellular membrane competes with Abl for myristoyl binding to stabilize the preactivated state and enhance allosteric activation.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

    Aarya Venkat, Grace Watterson ... Natarajan Kannan
    Isoform-specific variations in doublecortin-like kinases offer a new framework for understanding kinome-wide modulation of protein stability and catalytic activity.