Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Neuroscience

    Metabolic activity organizes olfactory representations

    Wesley W Qian, Jennifer N Wei ... Alexander B Wiltschko
    Metabolic activity across all living things represents an organizing principle for the sense of smell in humans and animals.
    1. Computational and Systems Biology
    2. Developmental Biology

    Patterning precision under non-linear morphogen decay and molecular noise

    Jan Andreas Adelmann, Roman Vetter, Dagmar Iber
    Statistical analysis of morphogen gradients indicates that non-linear morphogen decay does not lead to significantly increased patterning precision, and in fact, the opposite is observed far from the source.
    1. Cancer Biology
    2. Computational and Systems Biology

    Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

    Simon Grund Sørensen, Amruta Shrikhande ... Jakob Skou Pedersen
    Deficiencies of several DNA damage response genes can be predicted by their association with genome-wide mutation patterns.
    1. Computational and Systems Biology

    Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock

    Sara Ahadi, Kenneth A Wilson ... Ali Bashir
    Deep learning on fundus images provides a non-invasive, short time-scale biological aging clock that successfully identifies aging genes validated in a fly model.
    1. Computational and Systems Biology
    2. Ecology

    Emergent regulation of ant foraging frequency through a computationally inexpensive forager movement rule

    Lior Baltiansky, Guy Frankel, Ofer Feinerman
    Rather than complex decisions, it is the motion of individuals that allows for collective foraging regulation in ant colonies.
    1. Plant Biology
    2. Computational and Systems Biology

    The photosystem I supercomplex from a primordial green alga Ostreococcus tauri harbors three light-harvesting complex trimers

    Asako Ishii, Jianyu Shan ... Jun Minagawa
    The structure of the photosystem I (PSI) supercomplex in Ostreococcus tauri has revealed a unique hybrid of both plant-type and green algal-type PSI supercomplexes with three Lhcp trimers located at the ‘state 2’ position.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Bias in nutrition-health associations is not eliminated by excluding extreme reporters in empirical or simulation studies

    Nao Yamamoto, Keisuke Ejima ... Andrew W Brown
    Elimination of extreme reporters using Goldberg cutoffs does not always produce unbiased estimates of associations between nutrition intakes and health outcomes.
    1. Ecology
    2. Computational and Systems Biology

    Competitive interactions between culturable bacteria are highly non-additive

    Amichai Baichman-Kass, Tingting Song, Jonathan Friedman
    High-throughput measurements of simplified bacterial communities find that when multiple species jointly inhibit a focal species of interest, their individual effects do not add up, but are dominated by the strongest single-species effect.
    1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a live birth prediction model for evaluating human blastocysts from a retrospective study

    Hang Liu, Zhuoran Zhang ... Yu Sun
    The inclusion of the patient couple's clinical features along with blastocyst images increases live birth prediction accuracy.
    1. Computational and Systems Biology
    2. Neuroscience

    Multilayer brain networks can identify the epileptogenic zone and seizure dynamics

    Hossein Shahabi, Dileep R Nair, Richard M Leahy
    Aging and the duration of epilepsy can intensify the high-frequency desynchronization between the epileptogenic zone and the rest of the brain in early to mid-seizure.