Browse our latest Computational and Systems Biology articles

Coordinated regulation of co-complex members compensates for aneuploidy-induced stoichiometric imbalances in human cancer.

The LOTUS initiative builds, through the Wikidata knowledge graph, a virtuous cycle of data sharing practices for natural products research.

aLENS implements new parallel methods to resolve cytoskeletal assembly dynamics with high stability, physical consistency, and scalability.

A newly developed computational framework provides an overview of the extent, diversity, and relevance of the genes of unknown function in genomes and metagenomes.

The generalizability of CODOP in distinct world regions and its flexibility to reckon with the changing availability of hospital resources makes it a clinically useful tool potentially improving the outcome prediction and the management of COVID-19 hospitalized patients.

Orthologous proteins display different mutational robustness that can be leveraged to improve prediction of functional sequences.

Using a neural network to predict how green fluorescent proteins respond to genetic mutations illuminates properties that could help design new proteins.

Integrative analysis of multi-tissue transcriptomics data of mice subjected to cold, mild warm or room temperature places the thermal adaptation of individual tissues in a whole-organism perspective.

Highly reproducible and efficient human primordial germ cell differentiation was achieved through geometric confinement, which enabled quantitative dissection of the cell signaling driving this differentiation, revealing a major role of Wnt signaling is indirect by inducing Nodal signaling.

Genetic architecture of muscle secreted protein functions are dominated by sex.