Browse our latest Computational and Systems Biology articles

An energetic cost related to force rate is quantified in human arm movements, and minimizing this cost predicts smoothness without minimizing variance, unifies motor-planning of smoothness and movement duration, and may help resolve motor redundancies.

The copy-and-shift mechanism modelled in the insect central complex facilitates multimodal navigation, providing a general computation model explaining flexible navigation behaviours.

Influenza vaccination in humans stimulates novel B cell evolution that is detectable in germinal centers, but not the peripheral blood.

A novel quantitative framework to analyse the inner structure of tumour spheroids in terms of the mechanisms that underly growth.

The spatial-temporal computer model of plant root meristem combines biomechanics and biochemical scales to reveal design principles underlying cell polarity and anisotropic growth during root development.

The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.

Integrating circuit-level theories about population dynamics in motor cortex with behavioral-level theories about motor control.

Investigating how an artificial network of neurons controls a simulated arm suggests that rotational patterns of activity in the motor cortex may rely on sensory feedback from the moving limb.

Biofactoid is a tool that enables researchers to capture information about molecular interactions in a form that is both human-readable and machine-computable, thereby allowing this information to be integrated into public knowledge-bases and to be widely disseminated.

A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the original papers.