Browse our latest Computational and Systems Biology articles

Important nonlinear links between infection, inflammation, and disease severity were revealed using experimentally validated mathematical models.

Rare, virus-specific immune cells in human blood are automatically identified by machine learning algorithm T-REX and characterized for signature features needed for tracking and isolation.

ERK activation during induction of long-term synaptic plasticity is enhanced by synergistic interactions among signaling pathways mediated by the synaptically located GTPase-activating protein, and each pathway contributes to different ERK temporal dynamics.

Ubiquitous transcriptional factor-CBP/p300 interaction induces epigenetic and transcriptional bimodality, which can be utilized to tune mean gene expression and noise independently.

Promoter futile cycles can explain how subtle differences in genome folding sometimes generate large difference in gene expression.

Measurement of physiological intracellular Ca²⁺ signals following neural stimulation in vivo reveals distinct spatiotemporal characteristics that promote optimal salivary gland fluid secretion.

A novel comparative genomics framework identifies MECP2 network proteins targeted by existing drugs, with three drugs validated in an in vitro Rett syndrome model.

Genome editing, advanced live-cell microscopy, and computational modeling were combined to measure WNT/CTNNB1 signaling parameters at the single molecule level, revealing critical regulatory nodes in this important signal transduction pathway.

Integrated multi-scale, multi-tool approach to design novel 'evolution drugs' which can delay the emergence of antibiotic resistance by constraining bacterial evolutionary escape strategies.

NICEdrug.ch is a resource allowing systematic and large-scale computational analysis of drug biochemistry, enzymatic targets, and toxicity in the context of cellular metabolism.