Browse our latest Computational and Systems Biology articles

A novel quantitative framework to analyse the inner structure of tumour spheroids in terms of the mechanisms that underly growth.

The spatial-temporal computer model of plant root meristem combines biomechanics and biochemical scales to reveal design principles underlying cell polarity and anisotropic growth during root development.

The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.

Integrating circuit-level theories about population dynamics in motor cortex with behavioral-level theories about motor control.

Investigating how an artificial network of neurons controls a simulated arm suggests that rotational patterns of activity in the motor cortex may rely on sensory feedback from the moving limb.

Biofactoid is a tool that enables researchers to capture information about molecular interactions in a form that is both human-readable and machine-computable, thereby allowing this information to be integrated into public knowledge-bases and to be widely disseminated.

A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the original papers.

The application of topological network analysis on multicenter high-frequency intra-operative physiology data discovers a precise range of blood pressure during surgery predicting poor recovery in spinal cord injury patients.

Computational models of gating processes in an ion channel show how stability shifts upon ligand-binding and mutations are reproduced, which highlights mechanistic details and proposes a new role for symmetry in gating.

Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.