Browse our latest Computational and Systems Biology articles

The fast spreading of neural activity across the brain has a complex structure, imposed by the white-matter bundles.

Mice exploring a labyrinth freely for the first time learn a complex action sequence after a handful of rewards, exhibiting a learning rate 1000-fold higher than in commonly-used paradigms.

A very large number of place-field maps can be robustly learned by association of external cues with the grid-driven response, however plasticity in the grid-cell inputs renders the place-cell responses volatile.

The mechanism triggering HBV membrane fusion involves ERp57, a cellular protein disulfide isomerase, and ultimately leads to the exposition of a fusion peptide that was identified in the pre-S1 determinant.

A deep learning network can classify cardiac myocytes into drug-free and drugged categories and predict the impact of electrophysiological perturbation across the continuum of aging.

A mathematical model predicts that cell cycle duration acts as a transcriptional filter and directly affects cell diversity in early eukaryotic development.

Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.

Horizontal gene transfer between distantly related bacterial species is frequent and widespread and can be efficiently identified using alignment-free methods.

Ligand capture by cell surface receptor complexes sets the shape of the Nodal signaling pattern in zebrafish.

The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.