Browse our latest Computational and Systems Biology articles

Inflammatory dynamics are tailored to bacterial class through macrophage integration of microbial stimuli and cytokine feedback.

Almost a quarter of faculty evaluation documents from US and Canadian universities mention Journal Impact Factor and often imply that it measures research quality.

Human primary olfactory cortical regions can be parcellated into anatomically distinct areas based on whole-brain functional connectivity profiles, suggesting distinct, parallel functional pathways in the human olfactory system.

A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.

A novel algorithm, consensus non-negative matrix factorization (cNMF), accurately identifies gene expression programs underlying cell-type identity and cellular activities from single-cell RNA-Seq data.

Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.

Widespread, rapidly evolving disordered regions contain molecular features that are preserved over evolution and are associated with specific biological functions.

Calcium imaging is used to construct a model of Caenorhabditis elegans nervous system dynamics capable of predicting future behavioral switches on a trial by trial basis and across individual animals.

A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.

A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.