Browse our latest Developmental Biology articles

Primate-specific miR-934 mediates neurogenesis and downstream neuronal differentiation processes, modulating the expression of genes associated with the subplate, a region most prominent in primates, emerging during early cortical development.

Wnt/beta-catenin signaling is essential for the specification of dorsal cell fate in amphioxus, suggesting a common evolutionary origin for the formation of the dorsal organizer in chordates.

Maf and Mafb differentially regulate MGE-derived cortical and hippocampal interneuron subtype and regional fate in part through promoting the expression of Mef2c and Pnoc during mouse embryonic neurogenesis.

Tracheal and esophageal fate specification underlies human structural anomalies, multiple cancers, and human pluripotent stem cell approaches for generating respiratory and esophageal cell types for tissue engineering.

A computational strategy for extracting representative numerical features from 3D microscopy data enables in-depth quantitative analysis of cell and tissue organization through machine learning-driven data integration and context-guided visualization.

The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.

A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.

A new morphological structure evolved through extreme changes in cell height requires novel connections to an extracellular matrix network, which predates the origin of structure.

Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.

Genetic analyses reveal that the loss of Lin28a causes axial shortening with mild skeletal transformations via decreased PRC1 at Hox genes, establishing a new pathway in the “Hox code.”.