The jellyfish embryonic body axis is globally coordinated by conserved planar cell polarity (PCP) mechanisms and oriented by localised Wnt3 in two steps, highlighting PCP’s role in animal axis evolution.
Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.
A comparison of how two nematode species sense salts highlights how evolution can find different ways to establish asymmetry in small nervous systems to optimize the processing of chemosensory cues.
Kawsar Hossain, Madeline Smith ... Stephen W Santoro
The neurogenesis rates of some olfactory sensory neuron subtypes are selectively accelerated in mice that are exposed to odors that stimulate those subtypes.
Transgenic and pharmacological approaches reveal developmental elevations in glycolytic flux have an instructive role in promoting rod photoreceptor differentiation and maturation via activation of Wnt signaling.
Haley N Mendoza-Romero, Jessica E Biddinger ... Richard Simerly
Hypothalamic microglia play an essential role in mediating changes to feeding circuitry caused by exposure to maternal HFD that may contribute to developmental programming of metabolic phenotype.