A new example of niche formation, revealing the mode of niche cell migration, implicates extrinsic sources of positional information, and uncovers the pathway required for stereotypical positioning of the niche.
Rachael Kuintzle, Leah A Santat, Michael B Elowitz
The Notch signaling pathway can use its various ligands, receptors, and Fringe proteins to generate diverse intra- and intercellular signaling behaviors.
Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.
Pablo Sanchez Bosch, Bomsoo Cho, Jeffrey D Axelrod
In Drosophila, the planar cell polarity protein Flamingo is required by winners to maintain their status during cell competition in multiple models as they compete to occupy excessive territory within wildtype tissues.
Pénélope Tignard, Karen Pottin ... Marie Anne Breau
Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfactory axons.
Paolo Petazzi, Telma Ventura ... Antonella Fidanza
A novel tool is used to assess gene function in vitro by targeted endogenous transcriptional activation to unveil novel players in development and disease.
