The glial-specific role of betaPix during cerebral blood vessel development has been revealed by establishing a new betaPix conditional trap allele in zebrafish.
Genetic approaches identify Rtf1-dependent transcriptional pausing as an essential mechanism governing the deployment of the cardiac gene program during myocardial differentiation from the mesoderm.
Genetic perturbation of Afadin in the retina reveals its importance for the precise organization of the retinal layers while leaving neuronal fate and numbers unaffected.
ANKEF1 stabilizes the sperm axoneme by reinforcing the nexin–dynein regulatory complex, revealing a mechanical buffering mechanism essential for flagellar integrity and male fertility.
Physical gel models and numerical simulations have been created to study ferret brain gyrification and cortical malformations, while comparisons with human phenotypes aim to link genetics and brain morphogenesis.
Stephen A Banse, Christine A Sedore ... Patrick C Phillips
Computer screening identifies that the widely prescribed vitamin A derivative all-trans retinoic acid increases both longevity and late-life health in a powerful genetic model system.
