Lalanti Venkatasubramanian, Zhenhao Guo ... Richard S Mann
Ig domain family members DIP-alpha and Dpr10 are required in a subset of Drosophila leg motor neurons and muscles, respectively, to establish their fine terminal branching pattern and synapses.
A new computational framework provides a flexible and general approach for single and collective biological motion characterisation and phenotyping ideally suited for high-throughput timelapse screens.
Denise M Poltavski, Pauline Colombier ... Takako Makita
Second-order guidance, a novel mechanism by which an initial guidance cue controls expression of a second guidance receptor, is required for precise refinement of axon trajectories during PNS development.
Andrea Cosolo, Janhvi Jaiswal ... Anne-Kathrin Classen
Tissue damage induces a reversible cell cycle arrest in G2, which promotes survival and mitogenic signals to facilitate tissue regeneration but drives senescence-like phenotypes under chronic stress conditions.
Valerie S Salazar, Luciane P Capelo ... Vicki Rosen
A periosteal Bmp2 signaling center couples bone length to bone width during development and must be reactivated by clinical bone anabolic therapies to reduce fracture risk and accelerate fracture repair.
The Eyeless/Pax6 temporal transcription factor generates neuronal identity, connectivity, and flight navigation behavior within the conserved adult brain structure called the central complex.
David J Jörg, Elizabeth E Caygill ... Benjamin D Simons
A model of signalling pathways interacting with proneural gene expression explains the sequential patterning of the largest visual processing centre in the developing Drosophila brain.
Madhav Jagannathan, Ryan Cummings, Yukiko M Yamashita
Cell biological study reveals the mechanism by which multiple satellite-DNA-binding proteins cooperate to form chromocenter to encapsulate the full complement of chromosomes.
