Jean-François Le Garrec, Jorge N Domínguez ... Sigolène M Meilhac
A precise sequence of left-right asymmetries, combined with mechanical constraints, is sufficient to drive the looped morphogenesis of the embryonic heart tube, with potential impact for congenital heart defects.
Hironobu Okuno, Francois Renault Mihara ... Hideyuki Okano
Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape.
Alexis S Bailey, Pedro J Batista ... Margaret T Fuller
Post-transcriptional control by YTHDC2 is required to turn off the mitotic proliferation program and facilitate proper expression of the meiotic program to allow a clean cell fate transition in the germline stem cell lineage.
Jason Karch, Tobias G Schips ... Jeffery D Molkentin
Molecular pathways controlling autophagic cell death are regulated at the level of the lysosome through the activity of the pro-death Bcl-2 family member Bax/Bak.
Jennifer L Fogel, Daniel L Lakeland ... Francesca V Mariani
Specification and expansion during rib development is explained by Agent-Based Modeling while respecting the locality of decision-making that occurs as millions of cells coordinate their behavior to form and refine spatial pattern.
Christophe Gaillochet, Thomas Stiehl ... Jan U Lohmann
HEC transcription factors control the timing of cell fate transitions in a dynamic stem cell system, allowing plants to adapt their developmental program to diverse environments.
Two receptor tyrosine phosphatases having overlapping function for the determination of the final axon stabilizing layer is encoded for their cumulative cytoplasmic activity and ligand specificity in the visual system.
Dhananjay Chaturvedi, Heinrich Reichert ... K VijayRaghavan
Modeling adult muscle homeostasis, maintenance and repair will now be possible in Drosophila with the discovery of satellite cells equivalents in flight muscles.