Browse our latest Developmental Biology articles

Page 169 of 211
    1. Developmental Biology
    2. Neuroscience

    A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex

    Nicolas Renier, Chloé Dominici ... Alain Chédotal
    The somatosensory cortex doesn't integrate mixed bilateral inputs, as partially uncrossing projections from the whiskers duplicates their representation by segregating lateralized inputs from each side of the head.
    1. Developmental Biology

    Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition

    Yun Huang, Jong Kyoung Kim ... M Azim Surani
    Soon after fertilisation, a critical portion of the embryonic genome is switched on through the actions of maternally inherited Stella, in part through controlling the activation of transposable elements.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent

    Shanshan Ai, Yong Peng ... Aibin He
    During heart maturation, embryonic ectoderm development as a chromatin remodeler triggers transcriptional silencing, while H3K27me3 is a passenger that is not sufficient for gene silencing.
    1. Developmental Biology

    Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta

    Lyad Zamir, Reena Singh ... Eldad Tzahor
    Live imaging coupled with cell lineage tracing in chick and mouse embryos reveal that the cardiac regulatory gene Nkx2.5 is also transiently expressed in early extra-cardiac hemogenic angioblasts that migrate to the heart, yolk sac and dorsal aorta.
    1. Developmental Biology
    2. Evolutionary Biology

    Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

    Aaron L Fidler, Carl E Darris ... Billy G Hudson
    Collagen IV is a primordial extracellular matrix component associated with the transition to animal multicellularity, and enabled the formation and evolution of epithelial tissues.
    1. Cell Biology
    2. Developmental Biology

    Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland

    Yangguang Hao, Li Hua Jin
    Jumu is required for the proper differentiation of prohemocytes and the proliferation and location of PSC cells.
    1. Cell Biology
    2. Developmental Biology

    Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

    Wing Tak Wong, Gianfranco Matrone ... John P Cooke
    Bioinformatic analysis of gene expression in chimeric heterokaryons can identify novel regulators of cell lineage.
    1. Developmental Biology
    2. Neuroscience

    Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells

    Tao Jiang, Katie Kindt, Doris K Wu
    Emx2 reverses hair bundle orientation in sensory hair cells.
    1. Cell Biology
    2. Developmental Biology

    A nanobody-based toolset to investigate the role of protein localization and dispersal in Drosophila

    Stefan Harmansa, Ilaria Alborelli ... Markus Affolter
    Functionalized protein binders, anchored to specific regions along the cell cortex, provide a novel approach to directly modify protein localization and dispersal in vivo.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

    Shogo Sawaguchi, Shweta Varshney ... Tetsuya Okajima
    The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.