Browse our latest Developmental Biology articles

Page 35 of 215
    1. Developmental Biology

    Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells

    Marta Grzonka, Hisham Bazzi
    Unlike mouse embryos, mouse embryonic stem cells are able to use a SAS-6-independent pathway for imperfect centriole biogenesis that is associated with a rich centrosomal milieu and robust PLK4 activity.
    1. Developmental Biology
    2. Neuroscience

    Temporal transcriptomic dynamics in developing macaque neocortex

    Longjiang Xu, Zan Yuan ... Xiaozhong Peng
    A useful single-cell resource provides the prenatal macaque different cell types’ gene expression profiles in the parietal cerebral cortex lobe.
    1. Developmental Biology
    2. Neuroscience

    A new look at the architecture and dynamics of the Hydra nerve net

    Athina Keramidioti, Sandra Schneid ... Charles N David
    A novel pan-neuronal antibody has revealed the organization of the nerve net controlling all behavior in the simple cnidarian Hydra.
    1. Developmental Biology
    2. Neuroscience

    RNA fusion in human retinal development

    Wen Wang, Xiao Zhang ... Zi-Bing Jin
    Chimeric RNAs are widely distributed spatiotemporally during human retinal development and have important regulatory functions, such as silencing of CTNNBIP1-CLSTN1 biasing the progenitor cells toward the RPE cell fate at the expense of neural retinal cell fates.
    1. Developmental Biology

    Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila

    Chhavi Sood, Md Ausrafuggaman Nahid ... Sarah E Siegrist
    Notch signaling regulates the neuroblast intrinsic temporal program to determine when neuroblasts terminate their cell divisions during development.
    1. Developmental Biology

    Sperm induction of somatic cell-cell fusion as a novel functional test

    Nicolas G Brukman, Clari Valansi, Benjamin Podbilewicz
    The fertilizing potential of sperm correlates with their ability to induce viral-like fusion of somatic cells expressing JUNO.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta

    Sima Stroganov, Talia Harris ... Michal Neeman
    Expression of Bisphosphoglycerate mutase, a key enzyme affecting the release of oxygen from hemoglobin, is augmented in the murine placenta challenged by gestational hypoxia in mice while its expression is attenuated in placenta of human FGR.
    1. Developmental Biology
    2. Neuroscience

    Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

    Simon Desiderio, Frederick Schwaller ... Frederic Marmigere
    Combining mouse genetic, behavioral, and electrophysiological approaches revealed that a transcription factor is required to shape touch neurons' distal projections in the skin while dispensable for their survival and specification.
    1. Developmental Biology

    Coordination of cell cycle and morphogenesis during organ formation

    Jeffrey Matthew, Vishakha Vishwakarma ... SeYeon Chung
    The SP1/KLF transcription factor Huckebein controls endoreplication in the Drosophila salivary gland, ensuring proper morphogenesis during organ formation.
    1. Developmental Biology
    2. Evolutionary Biology

    Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator

    Paul Knabl, Alexandra Schauer ... Grigory Genikhovich
    ChIP-seq analysis reveals BMP signaling targets in a cnidarian and identifies ZSWIM4-6 as a dampener of the pSMAD1/5 gradient and a potential conveyor of the BMP-mediated gene repression.