Deep mutational scanning was used to comprehensively quantify the effects of mutations to influenza hemagglutinin and shows that the virus possesses a high inherent mutational tolerance at key antigenic sites.
Jeffrey I Boucher, Joseph R Jacobowitz ... Douglas L Theobald
The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
Metabolic exaptation of an anaplerotic nitrogen cycle between bundle sheath and mesophyll cells may explain the remarkably frequent convergent evolution of C4 photosynthesis.
Benjamin R Macadangdang, Amit Oberai ... Siavash K Kurdistani
The N-terminal domain in histone 2A serves as an evolutionary tool to enable greater chromatin compaction when genome size is disproportionately larger than the nuclear volume across eukaryotes.
Well-preserved fossils reveal an extreme morphological specialization of fly larvae, and broaden our understanding of the diversity of ectoparasitism in Mesozoic insects.
Jennifer Hirst, Alexander Schlacht ... Margaret S Robinson
A missing link between the AP complexes and COPI sheds light on the evolution of vesicle coat proteins and trafficking pathways in the earliest eukaryotes.
