Alexander J Tarashansky, Jacob M Musser ... Bo Wang
Mapping single-cell atlases throughout Metazoa systematically characterizes cell type diversity and the evolution of their associated gene expression programs.
Vita Stepanova, Kaja Ewa Moczulska ... Svante Pääbo
Purine biosynthesis is reduced in humans due to a single amino acid substitution in adenylosuccinate lyase that occurred subsequent to the divergence of modern humans from Neandertals.
Sumnima Singh, Patricia Bastos-Amador ... Miguel P Soares
Ggta1 deletion in mice shapes and reduces the microbiota pathogenicity and probably contributed to the natural selection of GGTA1 loss-of-function mutations in the ancestral primates that gave rise to humans.
Artificial selection for increased tibia length in mice made their skulls longer, narrower, and flatter, suggesting that even distant skeletal regions can evolve as correlated responses to selection acting locally.
Anjali M Prabhat, Catherine K Miller ... Jeremy M DeSilva
The human-like joint proportions of Australopithecus afarensis evolved independently, making 'Lucy' and her kind the earliest known evolutionary experiment in obligate bipedalism.
Rachel A Johnston, Philippe Vullioud ... Jenny Tung
In cooperatively breeding Damaraland mole-rats, transitioning to 'queen' results in extensive gene regulatory and morphological remodeling, but also costs to skeletal integrity that scale with reproductive investment.
High-level transposon insertional mutagenesis and a broader spectrum of resistance-conferring mutations for selected carbapenems facilitate the evolution of carbapenem resistance in Klebsiella pneumonia clinical isolates.
The newly opened genome of a kleptoplastic mollusk, Plakobranchus ocellatus, indicated that sequestered plastids retain their activity within the animal cell without horizontal algal gene transfer to the animal nucleus.