Browse our latest Genetics and Genomics articles

Page 11 of 148
    1. Genetics and Genomics
    2. Medicine

    EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

    Lianlei Wang, Xinyu Yang ... Nan Wu
    EPHA4 pathway dysfunction causes axon pathfinding defects, resulting in impaired coordinated left-right locomotion by disrupting neural patterning and the function of central pattern generators, thereby potentially leading to idiopathic scoliosis.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments

    Terence Li, Marcus Alvarez ... Noah Zaitlen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

    Laura Sophie Kremer, Guanbin Gao ... Nils-Göran Larsson
    Regulation of mitochondrial DNA copy number is highly tissue-specific and context-dependent, particularly in the presence of disease.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Minus the Error: Testing for Positive Selection in the Presence of Residual Alignment Errors

    Avery Selberg, Nathan L Clark ... Sergei L Kosakovsky Pond
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Evolutionary Biology

    Divergent C. elegans toxin alleles are suppressed by distinct mechanisms

    Stefan Zdraljevic, Laura Walter-McNeill ... Leonid Kruglyak
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Genetics and Genomics

    Kinesin-2 autoinhibition requires elbow phosphorylation

    Guanghan Chen, Zhengyang Guo ... Guangshuo Ou
    Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Systematic analysis of transcription factor combinatorial binding uncovers TEAD1 as an antagonist of tissue-specific transcription factors in human organogenesis

    Araceli Garcia-Mora, Joshua Mallen ... Nicoletta Bobola
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Convincing
    1. Cell Biology
    2. Genetics and Genomics

    Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

    San Pin Steve Wu, Elvis Quiroz ... Francesco J DeMayo
    Genome-wide epigenetic profiling reveals chromatin regions in the human myometrium involved in functional regulation and hormonal control during pregnancy.
    1. Genetics and Genomics

    Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression

    Shengze Yao, Yesu Jeon ... Jeannie T Lee
    Xist RNA’s influence extends beyond the X-chromosome and its autosomal influence can be perturbed genetically and pharmacologically.
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