Browse our latest Genetics and Genomics articles

Epidermal mechanosensory responses contribute to acute detection of noxious mechanical stimuli and promote a form of prolonged mechanical hypersensitivity.

Paleodemographic analyses in a hypothesis-testing framework show that the major life-history trait of seasonal migration has strong effects on long-term effective population sizes in a clade of songbirds.

Rtf1 HMD is related to H2B ubiquitination and its downstream H3K4 methylation in both C. neoformans and C. deneoformans, thereby affecting its yeast-to-hypha transition and virulence.

A high-resolution atlas of the mouse dopaminergic system was obtained using single-nuclei RNA sequencing and spatial transcriptomics revealing molecular changes in a prodromal model of Parkinson's disease.

Experiments in fruit fly larvae show that epidermal cells can communicate with sensory neurons to drive responses to pain.

Phosphoproteomics identifies diverse CaM kinase substrates, while genetic dissection reveals an unexpected antagonistic interaction with calcineurin signaling that operates in distinct neurons to regulate thermo-nociception in Caenorhabditis elegans.

Mammalian cells are capable of loading MCM2-7 to support DNA replication in the absence of ORC to permit extensive DNA replication in vivo.

Integrated multi-omics analyses reveal the metabolism-independent role of nuclear IDH1 in chromatin remodeling during human erythropoiesis.

New insights into nuclear genome organization were generated by comparing genome localization relative to three major nuclear locales- nuclear lamina, nuclear speckles, and nucleoli- across several human cell lines.