Browse our latest Genetics and Genomics articles

Page 10 of 153
    1. Genetics and Genomics
    2. Neuroscience

    Opioid Use Disorder: Identifying new targets in the fight against opioids

    Fernanda Laezza
    Experiments reveal that a time-dependent epistatic interaction influences how mice respond to opioids, and that intracellular fibroblast growth factors also influence opioid sensitivity.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deletion of the moeA gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism

    Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham
    Disrupting a single molybdenum cofactor gene allowed us to connect metabolic regulation of complex carbohydrates with cell organization, enabling genetic tuning of bacterial structural color for biomaterial applications.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Neisseria gonorrhoeae LIN codes provide a robust, multi-resolution lineage nomenclature

    Anastasia Unitt, Made A Krisna ... Odile B Harrison
    LIN code offers a reliable framework for classifying gonococcal population structure, enabling straightforward exploration of isolate relationships, from broad superlineage divisions to minute single allele differences.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
    Analysis of hundreds of single-cell genomes from Yellowstone National Park shows bacterial species are less cohesive than previously thought.
    1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips
    Computer screening identifies that the widely prescribed vitamin A derivative all-trans retinoic acid increases both longevity and late-life health in a powerful genetic model system.
    1. Genetics and Genomics

    Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D

    Diana Marcu, David R Sannino ... Adam J Dobson
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa

    Alain Garcia De Las Bayonas, Nicole King
    Up-to-date computational pipeline characterizes G-protein-coupled receptor (GPCR) repertoires in the closest relatives of metazoans, providing a framework to investigate the evolutionary origins and ancestral functions of key metazoan signaling pathways.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Lifestyles shape genome size and gene content in fungal pathogens

    Anna Fijarczyk, Pauline Hessenauer ... Christian R Landry
    A genomic analysis shows that the evolution of genome size and gene content among fungal pathogens in the class Sordariomycetes varies depending on their interactions with hosts and vectors.
    1. Genetics and Genomics

    Chromatin accessibility variation provides insights into missing regulation underlying immune-mediated diseases

    Raehoon Jeong, Martha L Bulyk
    Analyzing population-level chromatin accessibility data shows added benefit over utilizing only gene expression data in elucidating the genetic mechanism of disease-associated variants.