Browse our latest Genetics and Genomics articles

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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes

    Itamar Lev, Hila Gingold, Oded Rechavi
    In Caenorhabditis elegans histone methylation (H3K9me3) controls the synthesis of heritable small RNAs in a gene-specific manner and thus enables 'flagging' of newly-acquired genes.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO hyperactivity drives premature aging of Norad-deficient mice

    Florian Kopp, Mahmoud M Elguindy ... Joshua T Mendell
    Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Noncoding RNA: Aging well with Norad

    Filipa Carvalhal Marques, Igor Ulitsky
    In mice, deleting a long noncoding RNA drives premature aging.
    Version of Record
    Insight
    1. Genetics and Genomics

    An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

    Tom G Richardson, Sean Harrison ... George Davey Smith
    A resource to systematically explore the association between overall genetic risk for 162 risk factors and disease with 551 outcomes.
    1. Genetics and Genomics

    Genetic and environmental perturbations lead to regulatory decoherence

    Amanda Lea, Meena Subramaniam ... Julien F Ayroles
    Infection and metabolic syndrome lead to a loss of molecular regulation, and changes in molecular correlations are under genetic control as revealed by the presence of correlation quantitative trait loci.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A Y-chromosome shredding gene drive for controlling pest vertebrate populations

    Thomas AA Prowse, Fatwa Adikusuma ... Joshua V Ross
    A Y-chromosome shredding gene drive that depletes the pool of XY males and effects mate limitation could be a viable tool for vertebrate pest control.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Point of View: Hypothesis, analysis and synthesis, it's all Greek to me

    Ioannis Iliopoulos, Sophia Ananiadou ... Vasilis J Promponas
    Many scientific terms have been borrowed from ancient languages, but their modern usage often overlooks their etymology, as do many new terms coined by scientists.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

    Cheen Euong Ang, Qing Ma ... Howard Y Chang
    lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.
    1. Genetics and Genomics

    Neurodevelopmental Disorders: Beyond protein-coding genes

    Anna Lozano-Ureña, Sacri R Ferrón
    A long non-coding RNA called lnc-NR2F1 regulates several neuronal genes, including some involved in autism and intellectual disabilities.
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    Insight
    1. Cancer Biology
    2. Genetics and Genomics

    Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes

    Stevephen Hung, Alina Saiakhova ... Peter C Scacheri
    Non-coding mutations in microsatellite-instable (MSI) colorectal tumors are prevalent and activate cancer-specific enhancers, thereby disrupting gene expression control.