Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics
    2. Neuroscience

    CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

    Eric Deneault, Muhammad Faheem ... Stephen W Scherer
    Autism-associated iPSC-derived neurons mutant in CNTN5 or EHMT2 are hyperactive.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Requirements for RNA polymerase II preinitiation complex formation in vivo

    Natalia Petrenko, Yi Jin ... Kevin Struhl
    The requirements for preinitiation complex formation/stability and transcription by RNA polymerase II in yeast cells are different from those in vitro, thereby altering the current view of basal transcription.
    1. Genetics and Genomics

    Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation

    Riddhiman Dhar, Alsu M Missarova ... Lucas B Carey
    A genome-wide quantitative microscopy screen implicates mitochondria in single cell variation in proliferation and drug resistance in yeast.
    1. Genetics and Genomics

    Molecular safeguarding of CRISPR gene drive experiments

    Jackson Champer, Joan Chung ... Philipp W Messer
    Genes drives utilizing synthetic target sites and the split-Cas9 system have similar performance to standard drives.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans

    Gregory M Davis, Shikui Tu ... Peter R Boag
    The RNA-binding protein NHL-2 is required for small-RNA mediated transgenerational epigenetic gene regulation.
    1. Genetics and Genomics

    Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

    Sujatha Jagannathan, Yuko Ogata ... Robert K Bradley
    The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic effects on promoter usage are highly context-specific and contribute to complex traits

    Kaur Alasoo, Julia Rodrigues ... Daniel J Gaffney
    Re-analysis of large gene expression datasets with state-of-the-art quantification methods reveals additional candidate genes mediating complex trait associations.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Immune genes are hotspots of shared positive selection across birds and mammals

    Allison J Shultz, Timothy B Sackton
    Pathogens, particularly viruses, target the same genes over deep evolutionary time, resulting in shared signatures of positive selection and transcriptional responses at the same genes.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Fine-mapping cis-regulatory variants in diverse human populations

    Ashley Tehranchi, Brian Hie ... Hunter B Fraser
    A map of the genetic variants affecting chromatin accessibility in 1000 individuals from 10 diverse populations reveals how cis-regulatory variants impact transcription and disease.
    1. Genetics and Genomics

    Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

    Paul RHJ Timmers, Ninon Mounier ... Peter K Joshi
    Genomic associations with lifespan principally reflect heart disease/smoking/dementia but not other cancers, and distinguish lifespan differences of five years between top/bottom deciles of a score derived from DNA alone.