Browse our latest Genetics and Genomics articles

Integrated analysis of IFN-λ and HCV amino acid variation indicates the key role of host innate immunity in viral control.

An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.

Single-cell RNA-sequencing in fruit flies gives an unprecedented picture of how new genes are expressed during the formation of sperm.

Caenorhabditis elegans studies indicate that gain-of-function mutations in the presynaptic voltage-gated calcium, associated with familial hemiplegic migraine in humans, result in excitatory-inhibitory imbalance in the nervous system.

Modulating the nutrient sensor TORC1 only in neurons in C. elegans is sufficient to regulate systemic longevity via inter-tissue signals that remodel mitochondria networks in non neuronal cells.

Regulatory evolution allows paralogs to escape from strucural pleiotropy.

Nematode hermaphroditism has co-evolved with a self-sperm sensing mechanism that protects hermaphrodites from the detrimental effects of mating with males.

Hermaphroditic Caenorhabditis elegans slow the onset of mating-induced death through self-sperm-regulated insulin-like gene expression, which regulates the activity of the IIS/FOXO pathway, mTOR signaling, and the TFEB/HLH-30 transcription factor.

Young Caenorhabditis elegans hermaphrodites use their own sperm to protect against the negative consequences of mating.

Single-cell RNA-sequencing and germline substitutions provide novel insights into how testis is a hotspot for evolutionary innovation of genes, expression, and mutation at the single-cell level.