Browse our latest Genetics and Genomics articles

Page 118 of 143
    1. Genetics and Genomics

    Genome-wide quantification of the effects of DNA methylation on human gene regulation

    Amanda J Lea, Christopher M Vockley ... Jenny Tung
    mSTARR-seq identifies regions of the genome where DNA methylation causally impacts gene expression, providing a map of which epigenetic marks may influence trait variation.
    1. Genetics and Genomics

    Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis

    Richard G Melvin, Nicole Lamichane ... Ville Hietakangas
    The optimal macronutrient composition, macronutrient space, varies strongly between closely related species and is determined by genetic changes in regulatory genes that globally reprogram gene expression profiles of metabolic pathways.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

    Nodar Makharashvili, Sucheta Arora ... Tanya T Paull
    The CtIP DNA repair enzyme is required for the removal of transcription-associated lesions in eukaryotic cells.
    1. Cell Biology
    2. Genetics and Genomics

    Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

    Yael Riahi, Tal Israeli ... Gil Leibowitz
    mTORC1 inhibition by perinatal ER stress induces beta-cell growth arrest with subsequent development of diabetes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

    Colin D Meiklejohn, Emily L Landeen ... Daven C Presgraves
    Selfish genetic elements may either promote or prevent the evolution of reproductive barriers, depending on the extent of gene flow between species.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi

    Eric CH Chen, Stephanie Mathieu ... Nicolas Corradi
    Arbuscular mycorrhizal fungi generate nuclear diversity in the dikaryotic life-stage stage via inter-nucleus recombination.
    1. Genetics and Genomics

    Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila

    Iryna Shakhmantsir, Soumyashant Nayak ... Amita Sehgal
    Alternative splicing provides a mechanism to maintain oscillations of the circadian clock.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

    David G Hendrickson, Ilya Soifer ... R Scott McIsaac
    A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Life Expectancy: Advancing the aging biology toolkit

    Troy K Coody, Adam L Hughes
    A new device for isolating large quantities of old yeast cells expands the experimental boundaries of aging research.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The Aquilegia genome provides insight into adaptive radiation and reveals an extraordinarily polymorphic chromosome with a unique history

    Danièle L Filiault, Evangeline S Ballerini ... Magnus Nordborg
    The evolution columbine genus involved frequent mixing between incipient species, and one chromosome appears to have taken its own path.