In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
Genome-wide profiling of R-loops at near single-nucleotide resolution reveals distinct R-loop boundaries depending on the presence and location of the first exon-intron junction.
Peter D Heintzman, Grant D Zazula ... Beth Shapiro
The extinct stilt-legged equids of North America are not related to Asiatic asses or horses, but instead represent a distinct lineage outside of living equid diversity that became extinct in the terminal Pleistocene.
Greater phenotypic variation is exposed by mutations in a gene regulatory system compared to mutations in its constitutive components, namely the transcription factor and the promoter, alone.
Luisa F Pallares, Ronan Ledevin ... Sabrina Renaud
An association mapping in wild mice revealed the first candidate loci for within-population molar shape variation and the phenotypic impact of such candidate loci was quantified and validated.
Rasmus O Bak, Daniel P Dever ... Matthew H Porteus
The CRISPR/Cas9 system can be used with recombinant AAV6 donor delivery to facilitate simultaneous, targeted integration into multiple genetic loci in hematopoietic stem and progrenitor cells.