Browse our latest Genetics and Genomics articles

The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.

Human pancreatic islet high-resolution chromatin state maps generated from DNA methylation, open chromatin and ChIP-seq mark data facilitate the characterisation of regulatory mechanisms at type 2 diabetes genome-wide association study loci.

The mechanisms by which a retrotransposon called LINE-1 duplicates itself and spreads through the human genome are becoming clearer.

Dissection of a cis-regulatory element (CRM) in its native chromosomal context using CRISPR/Cas9 editing and novel 'Active Genetics' reveals new features of CRM function and insights into how such regulatory elements change during evolution.

The biology of sponges provides clues about how early animals may have dealt with low levels of oxygen.

Protein biosynthesis and protein quality control jointly determine protein production costs.

Gene duplication is a useful strategy to reduce intrinsic noise in gene expression, which can provide a selective advantage in scenarios of cost-benefit analysis of expression.

Transcription-factor-dependent noncoding RNA transcription illuminates components of a transcription-factor-dependent gene regulatory network that includes enhancer-associated long noncoding RNAs and is necessary for cardiac rhythm.

Fruit fly chromosomes are divided into discrete structural domains by regions of decompacted chromatin, suggesting a novel model for the formation of a known class of genetic elements.

The quiescence-driven mutational landscape reveals replication-independent mutagenesis as a novel evolutionary force.