Browse our latest Genetics and Genomics articles

Page 29 of 151
    1. Genetics and Genomics

    Resetting of H3K4me2 during mammalian parental-to-zygote transition

    Chong Wang, Yong Shi ... Jiawei Xu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis

    Erik Toraason, Alina Salagean ... Diana E Libuda
    To maintain genomic integrity during oocyte development, the tumor suppressor BRCA1/BRC-1 and the SMC-5/6 complex both repress intersister crossover recombination events while BRCA1/BRC-1 also specifically inhibits error prone repair of DNA breaks during meiotic prophase I.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

    Jessica Gray, Von Vergel L Torres ... Ian R Henderson
    Klebsiella pneumoniae has specific repertoires of genes required for growth in urine and serum, highlighting new targets for antimicrobial treatments of this important pathogen.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A single-cell atlas of the miracidium larva of Schistosoma mansoni reveals cell types, developmental pathways, and tissue architecture

    Teresa Attenborough, Kate A Rawlinson ... Matthew Berriman
    A comprehensive description of gene expression and organisation in the cells that constitute the blood fluke larvae responsible for finding and invading its intermediate host.
    1. Developmental Biology
    2. Genetics and Genomics

    The role of heterochronic gene expression and regulatory architecture in early developmental divergence

    Nathan D Harry, Christina Zakas
    Changes in the amount and timing of gene expression during early development contribute to evolutionary divergence and life-history changes, even within a species.
    1. Developmental Biology
    2. Genetics and Genomics

    sisterless A is required for activation of Sex lethal in the Drosophila germline

    Raghav Goyal, Ellen Baxter, Mark Van Doren
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

    Wei Q Deng, Nathan Cawte ... Sonia S Anand
    Epigenetic signature of maternal smoking contributes to smaller body size and lower birth weight in newborns of European and South Asian ancestry.
    1. Cancer Biology
    2. Genetics and Genomics

    Circulating small extracellular vesicle RNA profiling for the detection of T1a stage colorectal cancer and precancerous advanced adenoma

    Li Min, Fanqin Bu ... Shutian Zhang
    Whole-transcriptomic profiling of circulating small extracellular vesicle RNA facilitates the detection of T1a stage colorectal cancer and precancerous advanced adenoma.
    1. Genetics and Genomics

    Deficiency of IQCH causes male infertility in humans and mice

    Tiechao Ruan, Ruixi Zhou ... Ying Shen
    IQCH is required for acrosome and axoneme development during spermatogenesis in humans and mice.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank

    Ardalan Naseri, Degui Zhi, Shaojie Zhang
    ROH-DICE is an efficient method for detecting ROH clusters in biobank data, enabling the study of population history of large cohorts, and providing a new genome-wide association analysis approach for finding disease-causing loci with multi-marker recessive effects.
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