Browse our latest Genetics and Genomics articles

Replication origins in yeast are more widespread than previously believed.

A functional genetics approach reveals a novel role for odorant binding proteins in post-mating processes, with complex mechanisms of evolutionary change across closely related insect species.

Expression of the appropriate repertoire of membrane channels, essential for activity of flight-promoting central dopaminergic neurons of Drosophila, requires store-operated Ca²⁺ entry during late pupal development and early adults.

Genetic analyses and mathematical modeling reveal that disrupting genes essential for sex determination and fertility in Aedes aegypti leads to the production of sterile males, effectively suppressing mosquito populations.

Reconstructing human mobility patterns using historical period genomes illustrates how the Roman Empire’s military and economic activities catalyzed an era of transient movement against the backdrop of generations-long prehistoric migrations.

Variation in type XI collagen alters estrogen-dependent signaling in the extracellular matrix and is identified as a genetic risk factor for adolescent idiopathic scoliosis, a common childhood deformity.

Unveiling the high-confidence protein–protein interaction networks of human and fly α-arrestins provides insights into conserved and species-specific functional roles depending on their protein domains and motifs.

Eliminating eukaryotic initiation factor 2 (eIF2) from wild-type budding yeast had little impact on translation of individual mRNAs, including those with regulatory upstream open-reading frames, even when canonical initiation factor eIF2 activity was impaired.

Spatially-resolved transcriptomics and single-nucleus RNA-sequencing are applied to the human locus coeruleus to characterize the gene expression profiles of norepinephrine (NE) neurons and other cell populations in this critical brain region, with all data made publicly available.

CRISPR knock-outs and functional genomic approaches probe the regulatory mechanism restricting the Hox gene Ubx to butterfly hindwings, explaining color pattern differentiation from forewings.