Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics

    Is competition for cellular resources a driver of complex trait heritability?

    Olivier Naret, Yuval Simons ... Jonathan K Pritchard
    1. Evolutionary Biology
    2. Genetics and Genomics

    Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

    Florian Bénitière, Anamaria Necsulea, Laurent Duret
    Variation in the rate of alternative splicing across animals are mainly driven by differences in the rate of splicing errors.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene expression plasticity followed by genetic change during colonization in a high-elevation environment

    Huishang She, Yan Hao ... Yanhua Qu
    An integrative approach allows investigations of the relationship between an initial plasticity and the subsequent adaptive evolution during rapid adaptive modification of complex systems in the wild.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins

    Mathew J. Thayer, Michael B. Heskett ... Phillip A. Yates
    1. Cell Biology
    2. Genetics and Genomics

    Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

    Jana Muroňová, Zine Eddine Kherraf ... Christophe Arnoult
    CCDC146 is a structural component of the flagellum in sperm, located in the doublet microtubules of the axoneme, whose absence leads to multiple morphological anomalies of the flagellum.
    1. Genetics and Genomics
    2. Neuroscience

    Population clustering of structural brain aging and its association with brain development

    Haojing Duan, Runye Shi ... IMAGEN consortium
    1. Genetics and Genomics

    Characterization of caffeine response regulatory variants in vascular endothelial cells

    Carly Boye, Cynthia A Kalita ... Francesca Luca
    Caffeine modulates the genetic risk for cardiovascular disease through changes in target gene expression, likely due to regulation of transcription factor binding.
    1. Genetics and Genomics
    2. Cancer Biology

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy K. Lu
    1. Cell Biology
    2. Genetics and Genomics

    A seven-sex species recognizes self and non-self mating-type via a novel protein complex

    Guanxiong Yan, Yang Ma ... Wei Miao
    A giant multifunctional protein complex mediates mating-type recognition through a non-ligand–receptor mechanism in a multisexual species.
    1. Genetics and Genomics

    The genomic landscape of transposable elements in yeast hybrids is shaped by structural variation and genotype-specific modulation of transposition rate

    Mathieu Hénault, Souhir Marsit ... Christian R Landry
    The gain of transposable elements in yeast hybrids does not scale with genetic divergence levels and is most impacted by structural variations and multiple aspects of individual hybrid genetic backgrounds.
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