Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics

    Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery

    Christian D Mutti, Lindsey Van Haute ... Michal Minczuk
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcription: The plusses and minuses of DNA torsion

    Steven Henikoff, David L Levens
    A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.
    Version of Record
    Insight
    1. Developmental Biology
    2. Genetics and Genomics

    Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster

    Jyotsna Kawadkar, Pradyumna Ajit Joshi, Ram Kumar Mishra
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deletion of the moeA gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism

    Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics

    A genome-wide association study implicates the olfactory system in Drosophila melanogaster diapause-associated lifespan extension and fecundity

    Sreesankar Easwaran, Denise J Montell
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    Confirmation of HLA-II associations with TB susceptibility in admixed African samples

    Dayna Croock, Yolandi Swart ... Caitlin Uren
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Improved base editing and functional screening in Leishmania via co-expression of the AsCas12a ultra variant, a T7 RNA polymerase, and a cytosine base editor

    Nicole Herrmann May, Anh Cao ... Tom Beneke
    An optimized cytosine base editing system for Leishmania species improves editing efficiency, reduces toxicity, and ensures stable guide expression, enabling scalable loss-of-function screening and efficient creation of functional mutants.
    1. Genetics and Genomics
    2. Neuroscience

    Impact of liver-specific survival motor neuron (SMN) depletion on central nervous system and peripheral tissue pathology

    Monique Marylin Alves de Almeida, Yves De Repentigny ... Rashmi Kothary
    A liver-specific depletion of the survival motor neuron protein in a mouse model unveils a compelling and intricate connection between liver function and pancreatic abnormalities in spinal muscular atrophy.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation

    Porter M Hall, Lauren A Mayse ... Michelle D Wang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability

    Jia-Ying Su, Yun-Lin Wang ... Chien-Ling Lin
    The UA-dinucleotide ratio in UTRs is negatively correlated with RNA stability both in the massively parallel reporter assay and in vivo, and is prevalent in fast-turnover genes.
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