Genetic tools were generated and used to determine the neurotransmitters and neuropeptides used by individual cell types within the Drosophila central complex and to study their roles in sleep regulation.
Sexually antagonistic pleiotropy involving frequency-dependent traits like mating display maintains linkage blocks like inversions as balanced polymorphisms in simulation, and may explain common inversion polymorphisms maintained at intermediate frequencies.
Hirokazu Kimura, Kamel Lahouel ... Nicholas Jason Roberts
High-throughput characterization of all possible CDKN2A missense variants identifies functionally deleterious variants and establishes accuracy of variant effect predictors.
Novel tools that allow neuron-specific investigations of the structure controlling sleep regulation in fruit flies reveal the extent of neuronal heterogeneity.
Eric Weine, Samuel Pattillo Smith ... Arbel Harpak
The estimation of individual genetic effects across different contexts can be boiled down to a bias-variance trade-off, yet for complex traits, the joint consideration of numerous causal effects alters this trade-off.
