Browse our latest Genetics and Genomics articles

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    1. Cell Biology
    2. Genetics and Genomics

    Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation

    Simon Stenberg, Jing Li ... Jonas Warringer
    Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.
    1. Cell Biology
    2. Genetics and Genomics

    Circadian oscillations in Trichoderma atroviride and the role of core clock components in secondary metabolism, development, and mycoparasitism against the phytopathogen Botrytis cinerea

    Marlene Henríquez-Urrutia, Rebecca Spanner ... Luis F Larrondo
    The biocontrol fungus Trichoderma atroviride possess a functional circadian clock, whose components impact the production of secondary metabolites and also play a role in the interaction with fungi such as the phytopathogen Botrytis cinerea.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination

    Andrea J Lund, Kristen J Wade ... Elizabeth J Carlton
    Genomic approaches can be integrated with epidemiological and ecological studies to provide high-resolution answers to open questions about schistosomiasis transmission dynamics, offering a level of precision that is actionable, such that schistosomiasis-control programming can be tailored to regional contexts.
    1. Genetics and Genomics

    Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows

    Hyeonsoo Jeong, Nicole M Baran ... Soojin V Yi
    Comprehensive genomic and population genetic analyses of a non-recombining chromosome in white-throated sparrows reveal the actions of purifying selection, positive selection, and balancing selection, expanding our understanding of supergene evolution.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia

    Sean Akira Montgomery, Tetsuya Hisanaga ... Frédéric Berger
    Genomic imprinting in the bryophyte Marchantia polymorpha by Polycomb results in maternal dominance of embryonic gene expression.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pneumococcal genetic variability in age-dependent bacterial carriage

    Philip HC Kremer, Bart Ferwerda ... John A Lees
    Future vaccination strategies in pneumococcal disease should target specific bacterial serotypes for different host age groups.
    1. Genetics and Genomics

    Nomograms of human hippocampal volume shifted by polygenic scores

    Mohammed Janahi, Leon Aksman ... Andre Altmann
    Accounting for genetic information improved normative models of hippocampal volume in humans by accounting for change equivalent to around 3 years of normal loss for a person aged 65.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    BIRC6 modifies risk of invasive bacterial infection in Kenyan children

    James J Gilchrist, Silvia N Kariuki ... Thomas N Williams
    Defining the probability of bacterial disease among children with severe malaria allows the integration of bacteraemia and severe malaria genome-wide association study data, identifying a novel risk locus for invasive bacterial disease.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans

    Susanna Lemmelä, Eleanor M Wigmore ... Athena Matakidou
    Elevated growth differentiation factor-15 (GDF15) levels do not appear to be a causal factor in body mass index (BMI) in humans but higher BMI does cause increases in GDF15.
    1. Genetics and Genomics

    Genome-wide association study in quinoa reveals selection pattern typical for crops with a short breeding history

    Dilan SR Patiranage, Elodie Rey ... Christian Jung
    A new insight into quinoa diversity enables sequence-based breeding and functional genomics.