Browse our latest Genetics and Genomics articles

Integrated multi-omics analyses reveal the metabolism-independent role of nuclear IDH1 in chromatin remodeling during human erythropoiesis.

New insights into nuclear genome organization were generated by comparing genome localization relative to three major nuclear locales- nuclear lamina, nuclear speckles, and nucleoli- across several human cell lines.

Pyruvate and related metabolites are linked to reduced glaucoma risk among genetically predisposed individuals and mitigate disease in a mouse model, highlighting a potential metabolic mechanism of resilience.

Pairwise CRISPR screen identified FYN and KDM4 as key regulator of tyrosine kinase inhibitor resistance in triple negative breast cancer (TNBC).

Genetic tools were generated and used to determine the neurotransmitters and neuropeptides used by individual cell types within the Drosophila central complex and to study their roles in sleep regulation.

Sexually antagonistic pleiotropy involving frequency-dependent traits like mating display maintains linkage blocks like inversions as balanced polymorphisms in simulation, and may explain common inversion polymorphisms maintained at intermediate frequencies.

High-throughput characterization of all possible CDKN2A missense variants identifies functionally deleterious variants and establishes accuracy of variant effect predictors.