Browse our latest Genetics and Genomics articles

Page 8 of 142
    1. Cell Biology
    2. Genetics and Genomics

    The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2

    Adam D Longhurst, Kyle Wang ... David P Toczyski
    An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Template switching during DNA replication is a prevalent source of adaptive gene amplification

    Julie N Chuong, Nadav Ben Nun ... David Gresham
    Template switching during DNA replication is a frequent source of adaptive gene amplification.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Methylation Clocks Do Not Predict Age or Alzheimer’s Disease Risk Across Genetically Admixed Individuals

    Sebastián Cruz-González, Esther Gu ... John A Capra
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion

    Mehul Vora, Jonathan Dietz ... Cathy Savage-Dunn
    Smad and Schnurri transcription factors engage in context-dependent interactions as well as independent genomic activities, leading to regulation of collagen secretion to mediate body size regulation in C. elegans.
    1. Developmental Biology
    2. Genetics and Genomics

    Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

    Kleio Petratou, Martin Stehling ... Stefan Schulte-Merker
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    • Convincing
    1. Genetics and Genomics
    2. Cancer Biology

    Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions

    Lingqin Zhu, Lang Yang ... Jianqiu Sheng
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Risk factors affecting polygenic score performance across diverse cohorts

    Daniel Hui, Scott Dudek ... Marylyn D Ritchie
    Numerous related sample characteristics affect polygenic score performance, and incorporation of interaction effects increases both model and polygenic score performance.
    1. Genetics and Genomics

    Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes

    Shuai Zhang, Ruixue Wang ... Lin Sun
    Global analyses using aneuploid Drosophila revealed the dynamic roles of RNA m6A modification in regulating gene expression and development under genomic imbalance, highlighting its potential relationships with dosage-related effects.
    1. Genetics and Genomics

    Down Syndrome: How a gene fuels ear infections

    Sedigheh Delmaghani, Aziz El-Amraoui
    The DYRK1A enzyme is a pivotal contributor to frequent and severe episodes of otitis media in Down syndrome, positioning it as a promising target for therapeutic interventions.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

    Patsy R Tomlinson, Rachel G Knox ... Robert K Semple
    PIK3R1 mutations that cause immunodeficiency through PI3-kinase hyperactivation also cause SHORT syndrome, due to PI3-kinase hypofunction, attributable to PI3-kinase destabilisation and outcompetition by mutant PIK3R1.
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