Browse our latest Genetics and Genomics articles

The protein p53 negatively impacts the ability of a CRISPR screen to discriminate between essential and non-essential genes, hence, p53 status should be considered in these screens.

Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.

Alternative splicing of a single gene generates functional diversity amongst chromatin regulators.

The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient double strand break repair.

A retinal gene regulatory network prevents the formation of alternative cell fates from non-stochastic retinal progenitor cells.

A robust library preparation and variant calling strategy (DigiPico/MutLX) eliminates false positive single nucleotide variants from picogram quantities of DNA following whole genome amplification.

Mutations that allow tumors to evolve and become resistant to treatment can be readily identified with a new sequencing approach.

Short homology arms exposed by CRISPR/Cas9 cleavage can target integration at genomic CRISPR/Cas9 cut sites at high frequencies with reproducible precision using pGTag vectors in zebrafish and mammalian cells.

Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.

The Aire-dependent genes show a preference for short 3’UTR transcript isoforms resulting in the escape from the post-transcriptional repression mediated by miRNAs in medullary thymic epithelial cells.