Browse our latest Immunology and Inflammation articles

Molecular dynamics simulations reveal that lipid binding at antibody loops and framework regions stabilizes membrane interactions, providing molecular details for neutralization mechanisms and strategies for HIV-1 vaccine development.

CXXC1 is a pivotal epigenetic regulator that ensures T_reg homeostasis and suppressive function by interacting with FOXP3 to modulate H3K4me3 deposition at key signature genes.

Genetically diverse Mycobacterium tuberculosis complex strains induce a gamut of human granulomatous responses in vitro, with a role for IL-1β in aggregate formation.

Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection.

Multi-omics analysis shows that preeclampsia-specific immune cell network was regulated by Folr2⁺Ccl7⁺Ccl8⁺C1qa⁺C1qb⁺C1qc⁺ pro-inflammatory macrophages, which can induce the CD8⁺ and Th17 memory T cells generation while inhibiting the gMDSCs production.

Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.

Procoagulant microvesicles derived from ruptured immune cells fuel blood coagulation.

A subset of Alzheimer disease patients carry mutant microglia somatic clones which promote neuro-inflammation.

A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.