Browse our latest Immunology and Inflammation articles

Signaling through nicotinic acetylcholine receptors in enterocytes impacts barrier integrity in the Drosophila intestine by regulating formation of the peritrophic matrix.

After an injury to the skin, murine wounds upregulate apoptosis and efferocytosis pathways, which are required for effective healing and may similarly impact wound healing in diabetic patients.

Analysis of conventional and gnotobiotic mice showed that a MHC-E-restricted unconventional CD8 T cell population is retained in the small intestine epithelium by a commensal bacterium.

A single microRNA-binding site in a long non-coding RNA alters T cell responses in vivo by 'sponging' the miRNA to inhibit its gene regulatory function.

A biochemical probe targeting Tregs shows the importance of Tregs for B cell homeostasis and peripheral B cell reduction is caused by an activated T-cell-dependent mechanism.

HDAC3 regulates the development of pDCs and maintenance of homeostasis of hematopoietic progenitors with dendritic cell (DC) differentiation potential, mechanistically by repressing cDC1 associated genes in a deacetylase-dependent manner.

Cst7, a gene coding for protein cystatin F, is expressed by microglia in neurodegenerative disease models and mediates sex-dependent effects on microglial endolysosomal function and disease pathology.

Multidimensional study of signaling pathways and epigenomics investigates how TCR (T cell receptor) signaling and chromatin landscape interpaly and impact on Treg stability.

Clearance of engineered Salmonella which trigger regulated cell death is dependent upon the cellular 'bucket list,' which is determined both by cell death signaling pathway and by cell type infected.

Massive IgG and IgA antibody deposition in severe alcoholic hepatitis livers, targeting unique human proteins and exhibiting hepatocyte killing potential, suggests a role for cross-reactive anti-bacterial antibodies in severe alcoholic hepatitis pathogenesis.