Browse our latest Immunology and Inflammation articles

PLWH over a decade of ART showed a significant reshaping of the function and expression of inhibitory receptors across the CD8+ T cell landscape, ultimately leading to a decrease of CD107a TIGIT HIV-1-specific CD8+ T cells recovered by TIGIT blockade.

Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.

Identification of transcriptional changes in the hypothalamus during Influenza A virus infection enhances our understanding of mechanisms underlying long-lasting neurological disturbances, potentially informing future therapeutic interventions and improving patient outcomes.

SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.

Comparing the inflammatory proteome of healthy Tanzanian and Dutch adults highlights a pro-inflammatory phenotype and metabolic differences in Tanzanians, with the potential role of food-derived metabolites in driving inflammation.

CD8+ Trm cells' erosion role in oral lichen planus via IFN-γ, TNF-α, and IL17 cytokines has been revealed, addressing a gap in recurrent erosion studies.

A novel pathway of emergency myelopoiesis is induced by repetitive virus stimulation at peripheral barrier sites which bypasses the requirement of conventional pathways and expands myeloid infiltration in tissues.

Genetic and biochemical analyses in vitro and in vivo reveal how the novel protein FAM76B regulates inflammation.

The role of placental aging and metabolic stress in driving labor onset is demonstrated, with a novel mouse model of preterm labor in which injection of a prolyl hydroxylase inhibitor stabilizes placental hypoxia-inducible factor 1 and significantly shortens gestational length.