Browse our latest Immunology and Inflammation articles

Multi-omic profiling of tumor-infiltrating T cells provides new insights into the differences in the effectiveness of CDK4 inhibitor between human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma patients.

Inflamasomme inhibition prevents immune activation, HIV-1 pathogenesis and the splenic content of HIV-1 total DNA in humanized mice when administrated early after HIV-1 infection.

Sequence signatures can be used to discriminate between selected and non-selected immune repertoires at different stages only at the collective population level but not at the level of single cells.

A novel B cell receptor induced interleukin 10 (IL-10) production from B10 cells involves signal transducer and activator of transcription 5 (STAT5) mediated IL-6 production which induces IL-10 in an autocrine and paracrine fashion from B10 cells.

Compared to non-burn tissue, T cells in burn tissue have a pro-inflammatory rather than a homeostatic tissue-resident phenotype, and unconventional T cells in burn tissue have a higher cytotoxic capacity.

Fibroblast growth factor 21 blocks hepatic lipid influx and accumulation, prevents Kupffer cell activation, and inhibits the formation of hepatic lipid- and scar-associated macrophages, thereby likely inhibiting fibrogenesis in nonalcoholic steatohepatitis in humanized APOE*3-Leiden.CETP mice.

Human leukocyte antigen class I (HLA class I) polymorphisms dictate the degree of endo-lysosomal assembly, which can supplement endoplasmic reticulum assembly for constitutive HLA class I expression and increase the efficiency of cross-presentation.

Early IFN-I response dynamics are initiated in only fractions of cells, of which their epigenetic profile is transiently heritable and subject to the effects of quorum sensing.

The expression of DECTIN-2 family C-type lectin receptors on macrophages and monocytes is inhibited by the Th2 cytokine IL-4, which suggests a mechanism for inhibition of Th17 responses to MINCLE-dependent vaccination responses by underlying helminth infection.

A hallmark property of non-functional clonotypes was used to develop a universal and fully computational method for detection and correction of multiplex PCR-specific quantitative bias in adaptive immune receptor repertoire.