Browse our latest Immunology and Inflammation articles

The tongue is a unique barrier organ, which is constantly exposed to environmental pathogens, and therefore is expected to host an immune cell network ensuring local immune defence, which we characterised during development, health, and disease.

Mutated NLRP3 forms cryo-sensitive aggregates that induce inflammasome assembly distinct from the canonical NLRP3 inflammasome.

An amino acid dimorphism in HLA-C with an established impact on natural killer cell receptors plays an unexpected and significant role in T cell receptor recognition of HLA-C with relevance for tumor immunity.

Rat blood profiles support non-linear aging with distinct trajectory shifts, and these profiles could be used to predict non-overt illness in rats or aging intervention efficacy.

Novel cell-free biochemical experiments show that the host GTPase MxB can restrict the infection of alphaherpesviruses by disassembling the sturdy viral capsids so that they can no longer protect the viral genomes.

A restriction factor induced by interferons blocks the replication of herpesviruses by disassembling the capsid proteins surrounding their genome.

The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.

B-cell integrin co-stimulation promotes the formation of an actomyosin network that drives integrin-dependent immune synapse formation and B-cell activation.

Together, our multi-tissue single-cell data shows that CD56^bright NK cells accumulate in the periventricular brain regions of multiple sclerosis (MS) patients, bringing NK cells back to the spotlight of MS pathology.

Evidence that enhancer strength determines the extent of random monoallelic gene expression, and that even lineage defining genes thought to be expressed by all cells in a lineage display some degree of random monoallelic expression.