Browse our latest Immunology and Inflammation articles

Phosphorylation of the phosphatase SHP-1 by PKC-θ in natural killer (NK) cells induces SHP-1 inhibition, revealing a novel molecular pathway that sustains NK cell activation threshold.

Cellular, genetic, and biochemical assays shows that the application of a specific type of currents in mouse tendons induces an inflammatory response that favors the regeneration of the tissue, being a treatment for chronic tendinopathy lesions.

The prolyl hydroxylase domain 2 regulates the Treg development and function in a hypoxia-inducible factor 2α-dependent manner.

An atmospheric trigger, the respirable particulate matter boost microglia pathogenic activities in the context of CNS demyelination by activating TLR-4/NF-kB signaling axis in animal models of immune- and toxicity-induced demyelination, as well as myelinogenesis during postnatal development.

Sera from vaccinated subjects bound additional linear epitopes compared to sera from individuals with mild infection, in addition the pathways of escape from antibodies from vaccination were more uniform than those from mildly infected individuals.

Erythropoietin transiently remodels the hematopoietic stem and progenitor cells pool by directly inducing myeloid-erythroid-megakaryocyte-biased multipotent progenitor clones compensated at the population level by induction of myeloid-B-cell-dendritic-cell-biased clones.

Naturally short-lived turquoise killifish undergo systemic and mucosal spontaneous decline in antibody-repertoire diversity during aging, recapitulating in a few months the aging-dependent decline of adaptive immunity.

Genetically modified mouse model and comprehensive analysis reveal the molecular mechanisms regulating early T-cell development through intracellular TCRβ expression-mediated β-selection and independent cell survival signaling.

Lifetime imaging of endogenous metabolic coenzymes is sensitive to dynamic changes in macrophage activation in a live animal, providing a label-free imaging approach to study immunometabolism in vivo with single-cell, spatial, and temporal resolution.

A method to carefully measure the molecular distance between a site of interest and a reference surface by the repeated acquisition of the two image channels followed by the statistical calculation of the relative difference.