Browse our latest Immunology and Inflammation articles

Infusion of hematopoietic stem and progenitor cells rescues mice from lethal Group A streptococcal sepsis.

A multiomics, systems biology approach was used to define the metabolic and signaling programs that drive the fate and function of pancreatic tumor-associated macrophages.

High-throughput sequencing of the memory T cell receptor repertoire and machine learning can predict robust antibody and CD4 T cell response to de novo hepatitis B vaccine.

Granzyme A^-/- mice, which have contributed to a body of research into this enzyme, emerge to have a mixed C57BL/6J-C57BL/6N genetic background, compromising our understanding of granzyme A and highlighting a widespread problem for knockout mouse studies generally.

KLK10 is a flow-sensitive endothelial protein that serves as an anti-inflammatory, barrier-protective, and anti-atherogenic factor with therapeutic potential.

Fluorescent protein-based reporter mouse models revealed that thymic cooperative antigen transfer is mediated by preferential pairing between a particular thymic epithelial cell subset and specific subset(s) of thymic dendritic cells.

METTL3 and m6A modifications could alleviate endothelial activation and atherogenesis through accelerated degradation of oscillatory flow-induced EGFR mRNA expression.

Sorting nexin 9, a membrane curvature inducing protein, creates a distinct environment within clusters of the co-receptor CD28 and thereby allows T cell activation to proceed to a successful outcome.

Patients with different rs1990760 variants have a differential inflammatory response to severe SARS-CoV-2 infections, so that those with a TT genotype have an attenuated systemic inflammation and may not benefit from steroid therapy.

Prevaccination levels of transcriptional modules related to monocytes, dendritic cells, and other immune categories correlate with clinical malaria risk in RTS,S/AS01E-vaccinated African children, suggesting that certain monocyte subsets may inhibit RTS,S/AS01E-induced protective responses.