Browse our latest Immunology and Inflammation articles

Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.

Type I IFN is a key determinant of pathogenic neutrophil activity and drives tissue pathology through modulation of IL-18 levels during genital HSV infection.

Analysis of neo-splicetope-specific T cell responses strongly questions the idea that in vitro proteasome-catalyzed peptide splicing reaction simulates the in vivo situation with the same high fidelity as the in vitro generation of non-spliced epitopes.

Spliced peptides present on tumor cells can help to mount an immune response, but algorithms offer limited help in predicting which ones actually exist and perform this role in vivo.

The needs and challenges of AIRR-seq controls are presented.

At the transition from intrauterine to postnatal life, drastic environmental alterations are mirrored by changes in cellular immunity, which are in part immune cell intrinsic and have lasting health impact.

Genetic and molecular characterization showed that evolutionarily conserved flavin-containing monooxygenase (FMO-2) plays an important role in host defense in Caenorhabditis elegans, and its induction is dependent on conserved transcription factors, TFEB and PPAR-α.

Identification and characterization of the responses of T lymphocytes that are specific for 'self' tissue antigens, revealing the functional limits of immune tolerance.

Endotoxemia recruits fast-acting anti-inflammatory innate myeloid progenitors from bone marrow into regional lymphatics through release of pre-formed Ccl19 secondary to NF-κB-independent, Traf6/IκB kinase-dependent signaling.

Ggta1 deletion in mice shapes and reduces the microbiota pathogenicity and probably contributed to the natural selection of GGTA1 loss-of-function mutations in the ancestral primates that gave rise to humans.