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In the absence of ABCB7, B cell development is halted at the pro-B cell stage and stimulated splenic B cells have impaired proliferation and reduced class switch recombination.

Tumor-infiltrating regulatory T cells are regulated by the immunoreceptor CD300a, which suppresses signals from tumor-derived extracellular vesicles.

A major Th1 cytokine IFN-γ mediates mitochondrial damage that leads to mTORC1 inhibition and Paneth cells death.

Antibody production upon vaccination requires antigen-specific T follicular helper cells whose formation can be suppressed by pro-inflammatory cytokine signalling.

IgH repertoires of physically sorted and bioinformatically selected B cell subpopulations overlap and are characterised by distinct repertoire characteristics, while certain repertoire features correlate with the position of the constant region on the IgH locus.

Regnase-1, an RNase suppressing proinflammatory mRNAs, interacts with 14-3-3, which diminishes cytokine mRNA recognition and the nuclear-cytoplasmic shuttling of Regnase-1 under inflammatory conditions.

Natural antibodies play a fundamental role in anti-cancer immunity.

COVID-19 mRNA vaccine-elicited T cells recognize variants of concern and phenotypically differ depending on number of vaccine doses and prior SARS-CoV-2 infection status.

Inducible fate-mapping analysis demonstrates that neither microglia, CD11c⁺ activated microglia nor border-associated macrophages are replenished by bone marrow-derived cells in Alzheimer’s disease.

The orientation of the TCR extracellular domain is highly variable and coupled to characteristic structural changes throughout the TCR - CD3 complex.