Browse our latest Immunology and Inflammation articles

In-depth proteomic analyses of intestinal tissue-resident intraepithelial T lymphocytes reveals how these cells are adapted to the intestinal environment through increased cholesterol and lipid metabolism, tailored metabolic profiles, receptors for interacting with epithelial cells, and tightly regulated signalling pathways.

An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.

Intranasal immunization of inactivated whole cell of some Gram-negative bacteria induces very rapid and efficient protection against bacterial pulmonary by training alveolar macrophage response, which can be harnessed to design rapid-effecting vaccine against multidrug-resistant bacteria infection.

Probing of various culture conditions leads to fundamental advances in ex vivo production of plasmacytoid dendritic cells for use in immunotherapy.

Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.

The immune cells of macaques fed a Western-like diet adopt a pro-inflammatory profile.

In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.

Modern human diet patterns alter primate behavior and monocyte gene expression leading to monocyte polarization–experimental evidence of the evolutionary mismatch hypothesis.

Neolithic was a turning point for immune responses in Europeans, favoring tolerance against intracellular pathogens, promoting inflammation against extracellular microbes, and being related to current auto-immune diseases.

Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.