Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Neuroscience

    Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

    Sina C Rosenkranz, Artem A Shaposhnykov ... Manuel A Friese
    Inducing neuronal mitochondrial activity during central nervous system inflammation counteracts inflammation-induced neuronal electron transport chain deficiency and calcium toxicity, thereby protecting against neuronal loss in a multiple sclerosis mouse model.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

    Wiebke Nahrendorf, Alasdair Ivens, Philip J Spence
    Malaria remodels the spleen to imprint tolerance and reduce pathology in subsequent infections.
    1. Cell Biology
    2. Immunology and Inflammation

    Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

    Florence WJ Chioh, Siew-Wai Fong ... Christine Cheung
    COVID-19 survivors, who are at risk for vascular complications, would benefit from close monitoring and preventive therapy.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    The allosteric modulation of complement C5 by knob domain peptides

    Alex Macpherson, Maisem Laabei ... Jean MH van den Elsen
    Structural and functional analysis of a new class of low-molecular-weight antibody fragments, derived from bovine immunoglobulins, reveals their therapeutic potential against C5, a target for refractory inflammatory diseases.
    1. Immunology and Inflammation
    2. Neuroscience

    Microglial trogocytosis and the complement system regulate axonal pruning in vivo

    Tony KY Lim, Edward S Ruthazer
    In vivo time lapse imaging reveals that microglial trogocytosis of presynaptic elements is regulated by the complement system which controls axon morphogenesis in the developing brain.
    1. Immunology and Inflammation

    Seroconversion stages COVID19 into distinct pathophysiological states

    Matthew D Galbraith, Kohl T Kinning ... Joaquín M Espinosa
    Stratification of COVID19 patients using quantitative metrics of seroconversion reveals distinct pathophysiological stages after SARS-CoV-2 infection, including key differences in immune cell types, inflammatory makers, and markers of organ function.
    1. Cell Biology
    2. Immunology and Inflammation

    Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

    Leonie Zeitler, Alessandra Fiore ... Peter J Murray
    IL4i1 is an amino acid oxidase expressed in the mammalian immune system and snake venoms, which control diametrically opposite cell protection versus cell death pathways, respectively.
    1. Immunology and Inflammation

    Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

    Marco Künzli, Peter Reuther ... Carolyn G King
    T cell receptor signal strength correlates positively with Th1 generation during acute infection but negatively during chronic infection.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

    Kathryn Milne, Alasdair Ivens ... Philip J Spence
    Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates

    Yasmine Issah, Amruta Naik ... Shaon Sengupta
    Neonatal hyperoxia abrogates the circadian protection from influenza infection in recovered adults.