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Protein kinase Cδ, a kinase downstream of B-cell antigen receptor, is found to be essential for class switching to and production of IgG in the T-cell-independent type 2 immune response and for regulation of gut-residing bacteria.

SARS-CoV-2 infection and vaccination elicit antibodies that cross-react with other human coronavirus spike proteins, indicating the spike S2 subdomain as a potential target strategy to develop a pan-coronavirus vaccine.

Circadian clocks in murine myeloid cells are dispensable for circadian cytokine function, trafficking and endotoxic shock in response to LPS in vivo.

Med16 and GSK3b regulate interferon gamma-mediated MHCII expression in macrophages and are required for CD4+ T cell activation.

Complex I of the mitochondrial respiratory chain is necessary for interferon gamma-mediated responses in antigen-presenting cells and is required for CD4+ T cell activation.

In the tumor microenvironment, only specific subsets of cytotoxic and immunosuppressive tumor-infiltrating lymphocytes are endowed with active translation.

Goblet cells use distinct receptors and signaling pathways to independently perform mucus secretion and endocytosis of fluid-phase cargo with atypical trafficking to deliver lumenal substances to the immune system.

Acyloxyacyl hydrolase, the host lipase that detoxifies bacterial lipopolysaccharides, also deacylates oxidized phospholipids, preventing inflammasome activation in macrophages in vitro and ameliorating acute lung injury in vivo.

Single-cell transcriptomics of intraocular infiltrate in human HLA-B27-associated active anterior uveitis shows a unique composition and phenotype of leukocytes preferentially affecting dendritic cells.

Sepsis leads to lasting changes in the composition of the pre-existing memory CD8 T cell compartment leading to altered localization, changes in their transcriptional landscape and chromatin accessibility, differential function, and reduced capacity to control infection.